5 Best Obesity Clinical Trials

Best Obesity Clinical Trials – Overview

Obesity is one of the most prevalent health risks that endanger the health and well-being of adults and children in the United States. Recent studies show that all U.S. states now have an obesity rate above 30%, with several exceeding 40%, especially in the South and Midwest.

Obesity-related conditions, such as heart disease, stroke, type 2 diabetes, and certain types of cancers, are on the rise and have become the leading cause of premature death in the US. In addition, the estimated annual medical cost for adults with obesity compared to those of normal weight is approximately $2,500 to $3,500, contributing to total obesity-related healthcare costs of about $173 billion per year.

Scientists and scholars have studied this phenomenon for years and organized numerous obesity clinical trials. These trials are established to find better and more efficient ways to curb the obesity pandemic gripping the United States.

Top 5 Obesity Clinical Trials

In this article, we have listed the top obesity clinical trials in the US.

1 – Retatrutide Cardiovascular Outcomes Trial (TRIUMPH‑OUTCOMES)

Evaluates if Retatrutide reduces major cardiovascular events and slows kidney function decline in adults with obesity and CVD/CKD. Eligibility: adults 18+, BMI ≥27 with established atherosclerotic cardiovascular disease and/or chronic kidney disease. NCT06383390 is actively recruiting.

2 – Orforglipron Oral GLP‑1 Weight‑Loss Trial (ACHIEVE‑4)

Evaluate the weight loss efficacy and safety of once‑daily oral non‑peptide GLP‑1 agonist (Orforglipron) in adults with obesity (BMI ≥30 or ≥27+comorbidity). Active Phase 3 trial.

3 – CagriSema Combination Therapy Trial (REDEFINE‑1)

Assess the efficacy of weekly injection combining cagrilintide + semaglutide for weight loss in adults with obesity/overweight (BMI ≥30 or ≥27 + comorbidity). Phase 3, actively enrolling.

4 – Bariatric Surgery vs. Medication Comparative Trial (Cleveland Clinic)

Randomize adults (age 18–70, BMI 35–65) to bariatric surgery, semaglutide, or tirzepatide; compare 1-year weight loss and comorbidity improvement. Recruiting at Cleveland Clinic (NCT06803888).

5 – Pediatric GLP‑1 Medication Trial (ages 6–12)

Evaluate the safety and effectiveness of weekly semaglutide in children 6–12 with clinical obesity. Active Phase 3 trial building on prior liraglutide data.

Conclusion

These are the top 5 obesity clinical trials in the US. Make sure to visit the investigator’s official website to find specific eligibility criteria and the application process for participating in any of these studies.

Your contribution may help determine better and more efficient treatments for different obesity-related health and lifestyle problems.

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