ICD-10 Anemia | ICD-10 Anemia Coding Guidelines

Introduction to ICD-10 Anemia

ICD 10 code for anemia varies depending on the specific type and cause. The most commonly used ICD codes for Anemia are D64.9, D50.0, D53.9, D59.9, and D61.9.

What is Anemia?

Anemia is a blood disorder associated with a low red blood cell (RBC) count in the blood.

A low RBC count can occur due to many reasons:

  • The body doesn’t make sufficient red blood cells (as in a bone marrow disorder or nutritional deficiency)
  • It destroys many red blood cells (even the healthy cells) (as in autoimmune diseases).
  • It loses many red blood cells ( for example, excessive blood loss)

Symptoms of Anemia:

Most of the symptoms of anemia are associated with the lack of oxygen in the body. Following are some symptoms of anemia:

  • Headache and lethargy
  • Lightheadedness or dizziness
  • Pounding heartbeats and arrhythmias
  • Body aches ( including joint pain and muscle aches)
  • Growth issues
  • Pale skin
  • Shortness of breath

ICD-10-CM Coding for Anemia:

ICD (International Classification of Diseases) coding is introduced by the World Health Organization (WHO). This coding system makes the documentation process simple and efficient. It covers the diagnosis, treatment, and healthcare services in a healthcare system, including billing and insurance.

ICD-10 Anemia Coding Guidelines:

ICD-10 Anemia

ICD-10 Anemia – Anemia Coding Guidelines

Anemia associated with malignancy:

When a patient is admitted for management id anemia associated with malignancy, the treatment is only for anemia. Appropriate code for malignancy is sequenced as the principal diagnosis or first-listed Dx, followed by the code for Anemia.

Anemia Associated with chemotherapy, radiation therapy, and immunotherapy:

When the reason for admission is the management of anemia associated with the adverse effect of administration of chemotherapy or immunotherapy and the only treatment for anemia. Then always code anemia as a principal or first-listed diagnosis, followed by the appropriate code for neoplasm and then the adverse effect.

List of All ICD-10 codes for anemia and related blood disorders:

Chapter 3 of the ICD-10 coding manual book approved for medical coding and billing covers anemia.

Following are the ICD-10 codes for anemia:

D50- Iron deficiency anemia

  • Hypochromic anemia (increased hemoglobin and reduced RBCs)
  • Asiderotic anemia (colorless anemia)

D50.0- Chronic blood loss-related iron deficiency-anemia

  • Chronic posthemorrhagic anemia

D50.1- Sideropenic dysphagia (web-like membranes in the throat making swallowing difficult, caused by iron deficiency anemia). Also called:

  • Kelly-Paterson syndrome
  • Plummer-Vinson syndrome

D50.8- Other iron deficiency anemias

D50.9- Unspecified iron deficiency anemia

D51- Anemias related to vitamin B12 deficiency

D51.0- Vitamin B12 deficiency anemia due to intrinsic factor (IF) deficiency. It includes:

  • Addison anemia (stomach doesn’t produce intrinsic factor (IF), which is responsible for the absorption of vitamin B12)
  • Pernicious Anemia
  • Biermer Anemia (another name for pernicious anemia)
  • Intrinsic factor deficiency by birth

D51.1- Vitamin B12 deficiency due to selective vitamin B12 absorption with proteinuria (high levels of protein in urine)

  • Megaloblastic hereditary anemia

D51.2- Transcobalamin II deficiency anemia (transcobalamin II is a protein that transports vitamin B12 throughout the body)

D51.3- Other dietary vitamin B12 deficiency anemia. Such as Vegan Anemia ( elimination of meat in the diet leading to the deficiency of Iron)

D51.8- Other vitamin B12 deficiency anemias

D51.9- Unspecified vitamin B12 deficiency anemia

(Default category code) D52- Folate deficiency anemia (deficiency of folic acid (vitamin B9) in the blood)

Below are the sub-category codes for D52:

D52.- Dietary Folate deficiency anemia OR

  • Nutritional megaloblastic anemia

D52.1- Drug-induced folate deficiency anemia

D52.8- Other folate deficiency anemias

D52.9- Unspecified folate deficiency anemia

D53- Other nutritional anemia (also includes megaloblastic anemia that is unresponsive to vitamin B12 it folate therapy)

D53.0- Protein deficiency anemia

  • Amino acid deficiency anemia
  • Orotaciduric anemia (decreased pyrimidine synthesis that is required for erythrocyte membrane synthesis- characterized by increased orotic acid in the urine)

D53.1- Other megaloblastic anemias not elsewhere classified

D53.2- Scorbutic anemia (due to deficiency of vitamin C)

D53.8- Other specified nutritional anemias

  • Anemia associated with the deficiency of copper, molybdenum, and zinc

D53.9- Unspecified nutritional anemia

D55- Anemia due to enzyme disorders

D55.0- Anemia due to glucose-6-phosphate dehydrogenase (G6PD) deficiency

  • Favism (hemolysis of red blood cells faster than their exhibition

D55.1- Anemia due to other disorders of glutathione metabolism

D55.2- Anemia due to disorders of glycolytic enzymes

D55.3- Anemia due to disorders of nucleotide metabolism

D55.8- Other anemias due to enzyme disorders

D55.9- Anemia due to enzyme disorder, unspecified

D56- Thalassemia (the body does not make enough hemoglobin)

D56.0- Alpha thalassemia

D56.1- Beta thalassemia (intermediate and major)

D56.2- Delta-beta thalassemia

D56.3- Thalassemia trait (thalassemia beta minor)

D56.4- Hereditary persistence of fetal hemoglobin (HPFH)

D56.5- Hemoglobin E-beta thalassemia

D56.8- Other thalassemias

D56.9- Thalassemia, unspecified

  • Mediterranean anemia (underproduction of hemoglobin)
  • Thalassemia (mixed)

D57- Sickle cell disorders

D57.0- Sickle cell anemia with crisis

D57.00- Hb-SS disease (sickle cell anemia) with crisis, unspecified

D57.01- Hb-SS disease with acute chest syndrome

D57.02- Hb-SS disease with splenic sequestration

D57.1- Sickle cell anemia without crisis

D57.2- Double heterozygous sickling disorders

D57.20- Hb-C disease without crisis

D57.211- Hb-C disease with acute chest syndrome

D57.212- Hb-C disease with splenic sequestration

D57.219- Hb-C disease with crisis, unspecified

D57.3- Sickle-cell trait

  • Hb-S trait
  • Heterozygous hemoglobin S (HbAS)

D57.40- Sickle-cell thalassemia, without crisis

D57.411- Sickle-cell thalassemia with acute chest syndrome

D57.412- Sickle-cell thalassemia with splenic sequestration

D57.419- Sickle-cell thalassemia with crisis unspecified

D57.8- Other sickle-cell disorders

D57.80- Without crisis

D57.811- With acute chest syndrome

D57.812- With splenic sequestration

D57.819- With-crisis, unspecified

D58- Other hereditary hemolytic anemias

D58.0- Hereditary spherocytosis (sphere-shaped RBCs)

  • Minkowski-Chauffard syndrome

D58.1- Hereditary elliptocytosis (elliptical-shaped RBCs)

  • Ovalocytosis

D58.2- Other hemoglobinopathies

  • Congenital Heinz body anemia
  • Unstable hemoglobin hemolytic disease

D58.8- Other specified hereditary hemolytic anemias

  • Stomatocytosis (normal central zone of pallor is replaced by a slitlike pattern)

D58.9- Unspecified hereditary hemolytic anemia

D59- Acquired hemolytic anemia

D59.0- Drug-induced autoimmune hemolytic anemia

D59.1- Other autoimmune hemolytic anemias

D59.2- Drug-induced autoimmune hemolytic anemia

D59.3- Hemolytic-uremic syndrome (associated with clogged blood vessels in kidneys and kidney failure)

D59.4- Other nonautoimmune hemolytic anemias

(mechanical, microangiopathic, and toxic)

D59.5- Paroxysmal nocturnal hemoglobinuria

D59.6- Hemoglobinuria due to hemolysis from other external causes (from exertion, march, and paroxysmal cold

D59.8- Other acquired hemolytic anemias

D59.9- Unspecified acquired hemolytic anemia

D60- Acquired pure red cell aplasia

D60.0- Chronic acquired pure red cell aplasia

D60.1- Transient acquired pure red cell aplasia

D60.8- Other-acquired pure red cell aplasias

D60.9- Unspecified, acquired pure red cell aphasia

D61- Other aplastic anemias

D61.0- Constitutional aplastic anemia (congenital, primary, infants)

D61.1- Drug-induced aplastic anemia

D61.2- Aplastic anemia due to other external agents

D61.3- Idiopathic aplastic anemia

D61.8- Other specified aplastic anemias

D61.9- Unspecified aplastic anemia

D62- Acute posthemorrhagic anemia

D63- Anemia in chronic diseases classified elsewhere

D63.0- Anemia in neoplastic disease

D63.1- Anemia in chronic kidney disease

D63.8- Anemia in other chronic diseases classified elsewhere

D64- Other anemias

D64.0- Hereditary sideroblastic anemia

D64.1- Secondary sideroblastic anemia due to disease

D64.2- Secondary sideroblastic anemia due to drugs and toxins

D64.3- Other sideroblastic anemias

D64.4- Congenital dyserythropoietic anemia

D64.81- Anemia due to antineoplastic chemotherapy

D64.89- Other specified anemias

D64.9- Unspecified anemias

What are the 4 Types of Anemia?

Types of anemia differ according to the causes of a low red blood cells count in the body. Following are some specific types of anemia:

#1 What is an Iron Deficiency Anemia?

As evident from its name, iron deficiency anemia refers to the deficiency of Iron in the body. Iron is an essential part of hemoglobin. Hemoglobin is a protein that binds oxygen in red blood cells. It acts as a carrier of oxygen.

#2 What is an Aplastic Anemia?

Aplastic anemia is an acquired or inherited disorder related to bone marrow dysfunction. The bone marrow cannot produce sufficient red blood cells in this kind of anemia. It is because the bone marrow produces different types of blood cells. People undergoing chemotherapy or having diseases that damage bone marrow are at risk of developing this kind of anemia other than those who inherit the causes. Its treatment is more aggressive, including blood transfusions, bone marrow transplants, and medicines.

#3 What is a Pernicious Anemia?

Pernicious anemia is associated with vitamin B12 deficiency in the body. This deficiency can be because of the lesser uptake of vitamin B12 in food or the malabsorption of vitamin B12 in the intestines. Vitamin B12 deficiency leads to decreased production of red blood cells. People having malnutrition and intestinal issues with the absorption of vitamin B12 are at risk of developing this type of anemia. Vitamin B12 supplements and dietary modifications are defined to improve the condition.

#4. What is a Hemolytic Anemia?

Hemolytic anemia refers to the destruction of red blood cells before they complete their standard lifespan (120 days). This destruction can be due to an autoimmune disorder, or it can be inherited (mutation in genes that control red blood cell production and lysis). Treatment of underlying causes, blood transfusions, and medicines may prove helpful.

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Current Version
January 10, 2023
Written By
Asher Ashfaq, OMPT, PT, CPC, CMP

In brief: Your Guide to Anemia; U.S Department of Health and Human Services; NIH Publication No. 11-7629A; 2011.


Imtiaz Ahmad; ICD-10 Codes for Anemia; DocCharge; 2020.

Anemia; WebMD editorial; 2022.


ICD-10 Version:2019 ; World Health Organisation



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