4 Laser Eye Surgery Clinical Trials in the US

Laser Eye Surgery Clinical Trials in the US

Eyes are probably our most precious asset. A world without vision is simply dark. However, it is not always possible to avert eye disorders, diseases, or injuries.

In such cases, the patient needs to undergo correcting eye surgery. The success of any medical or surgical treatment depends on how the process proves itself during the clinical trials.

Current Laser Eye Surgery Clinical Trials in the US

Here is a list of the top laser eye surgery clinical trials in the US:

1 – The RESTORE Study, a Randomized, Controlled, Masked (Reading Center) Prospective Study

This is a “randomized, controlled, masked (reading center) prospective study of the effectiveness and safety of the ocular therapeutics dextenza (dexamethasone ophthalmic insert) 0.4 mg for the treatment of post-operative inflammation and pain in patients who have undergone PRK laser eye surgery.

Vance Thompson Vision sponsors the RESTORE study in collaboration with Ocular Therapeutix, Inc.

This study compares the outcomes and patient preferences for an intracanalicular dexamethasone (0.4 mg) insert versus conventional steroid drop treatment in the contralateral eye after bilateral PRK surgery.

Details of RESTORE Study

  • Phase – Phase 4
  • Study Type – Interventional
  • Enrolment – 20 participants

For complete information and details of participation, please contact – Keeley Puls (605 – 371 – 7075) / [email protected]

2 – DEXTENZA Compared to Topical Prednisolone in Patients Undergoing Bilateral LASIK Surgery

This is a prospective, single-center, open-label, investigator-sponsored, randomized clinical study that will investigate the results for patients undergoing bilateral LASIK eye surgery through treatment with dexamethasone intracanalicular insert as compared to conventional tropical care prednisolone.

All applicants will receive eye surgery treatment.

This study aims to compare outpatient preferences and treatment results between the intracanalicular dexamethasone (0.4 mg) insert and the conventional steroid drop treatment method in the contralateral eye after bilateral LASIK eye surgery.

Details of DEXTENZA Study

Details of DEXTENZA Study

Details of DEXTENZA Study

  • Phase – Phase 4
  • Study Type – Interventional
  • Enrolment – 20 participants

For additional details and information on this study, please contact – Sara Thiede (701 – 566 – 5390) / [email protected]

3 – Randomized, Non-inferiority Trial Comparing SMILE and LASIK

The randomized, non-inferiority trial comparing SMILE and LASIK should not be listed under US clinical trials as it is sponsored by the Singapore National Eye Centre, indicating it is primarily conducted in Singapore.

This study is set to compare the effectiveness of SMILE (small incision lenticule extraction) eye surgery with the results obtained after undergoing LASIK (Laser In-Situ Keratomileusis) eye surgery.

The main aim of this clinical trial is to determine whether SMILE is non-inferior to LASIK regarding results after 3 months from the eye surgery.

Clarify that the study design involves comparing the two eyes of the same participant, where one eye undergoes SMILE and the other undergoes LASIK, which is a significant detail in understanding the trial’s setup. After expressing consent, participants eligible to undergo LASIK eye surgery will be enrolled in the study.

Details of Randomized Trial Comparing SMILE and LASIK

  • Phase – Phase 4
  • Study Type – Interventional
  • Enrolment – 70 participants

For additional details and information, feel free to contact Donald T. Tan, FRCS (Ed.) (6562263395) / [email protected]

4 – Long-term LASIK Follow-up Study

LASIK eye surgery is the most commonly used technique for corneal refractive surgery to treat myopia correction. This is one of the rare studies that have been conducted to evaluate the long-term results after LASIK eye surgery.

This study aims to assess the long-term results (after 5 to 10 years) of LASIK eye surgical treatment to determine the stability of visual outcomes and long-term effects on corneal morphology with in vivo confocal microscopy.

To be eligible for participation in the Long-term LASIK Follow-up Study, you must have undergone LASIK eye surgery specifically at the Kellogg Eye Center to correct myopia or myopic astigmatism using either a femtosecond laser or a microkeratome within the last 5 to 10 years.

Details of Long-Term LASIK Follow-up Study

  • Phase – Phase 4
  • Study Type – Observational
  • Enrolment – 51 participants

For complete details and information on eligibility criteria and the participation process, contact Kellogg Eye Center, Ann Arbor, Michigan, United States, 48105.


These are the current top laser eye surgery clinical trials in the US. If you want the precise details of the participation process and information on the application, feel free to use the contact details provided.

See Also

Laser Eye Surgery Cost

Government Grants for LASIK

Grants for Visually Impaired Adults

Foster Grant Reading Eye Glasses

How much do clinical trials pay



Current Version
July 21, 2021
Written By
Shubham Grover
April 16, 2024
Updated By
Andleeb Asghar, PharmD

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