Dental Regeneration Clinical Trials in 2023

Tooth Regeneration Clinical Trials 2021 Tooth Regeneration Clinical Trials 2021

Dental regeneration is quite a novel approach to repairing teeth from several dental conditions. Since 2000, dental stem cells have been identified and used for investigating several applications for tooth repair.

Our teeth are a highly valuable part of our bodies. They not only help us enjoy delicious foods but also are an important esthetical aspect of our look. Moreover, healthy teeth give us a natural and good-looking smile.

We understand how important keeping our teeth healthy is, and therefore, we undertook an interesting search on the current clinical trials on dental regeneration using stem cells in 2023 (USA).

Keep reading to learn more about this fascinating field and how scientists are advancing dental care using stem cells.

What are Stem Cells?

Tooth Regeneration Clinical Trials

Dental regeneration clinical trials in 2023 – What are Stem Cells

Stem cells can be viewed as “mother cells.” They can give rise to many types of cells in our body. In fact, the Embryo is considered the primary human stem cell: every other type of cell we have as adults is derived from this single cell.

As the embryo develops, though, different types of stem cells are born, which give rise to the many tissues found in our bodies.

What About Dental Stem Cells?

Dental Stem Cells are a specific type of “mother cells.” They can develop into the different parts that form our teeth and the structures that support them.
In comparison, there are more types of stem cells, like hematopoietic stem cells, neural stem cells, or muscle-tissue stem cells. They usually develop into the blood components, the nervous system (brain, spinal cord, and nerves), and muscles, respectively.

Now that you had a glance at stem cells let’s overview the types of dental stem cells and their applications to dental conditions. Keep it on to learn about the latest clinical trials on dental stem cells.

Types of Dental Stem Cells and the Conditions They Are Used For

Both children and adults have stem cells surrounding and taking part of teeth. They participate in several functions, like supporting and helping our teeth stay healthy.

Scientists have found six types of dental stem cells that can be used for treating several dental conditions. By retrieving stem cells from teeth and their surroundings, scientists can make them grow in the lab and further use them when needed.

Types of Dental Stem Cells

The six types of dental stem cells are:

  • Dental pulp stem cells: Found in the pulp, the central part of teeth.
  • Stem cells from dental exfoliated teeth: These types of stem cells are retrieved from baby teeth.
  • Dental follicle stem cells: These stem cells are found in the follicle, the covering of growing teeth.
  • Gingival fibroblastic stem cells: These stem cells are found in the gums.
  • Stem cells from apical papilla: These can be found in the papilla, located at the base of teeth roots.
  • Periodontal ligament stem cells: These are found surrounding the teeth roots.

Some Conditions For Which Scientists Are Applying Dental Stem Cells

  • Pulpitis: Inflammation of the dental pulp.
  • Periodontitis: Inflammation of tissues bordering teeth.
  • Periapical lesions: Problems with the tip of teeth roots or the alveolar bone (the socket where the teeth are inserted, which is a part of the jaw bone).
  • Tooth loss.

Dental Regeneration Clinical Trials in 2023 in the USA

Tooth Regeneration Clinical Trials

Dental regeneration clinical trials in 2023 – Dental Regeneration Clinical Trials in 2023 in the USA

Now that we have reviewed the different types of dental stem cells and their applications, let’s dive into the current clinical trials in dental regeneration in the USA in 2023.

For this purpose, we performed a search on, looking for the following keywords:

  • “Dental regeneration;”
  • “Dental stem cells;” and
  • “Tooth regeneration.”

Inclusion Criteria

  • We included all studies that fit the following characteristics:
  • The study is recruiting participants.
  • The study is active but not recruiting participants.
  • The study is not yet recruiting participants.
  • The study is recruiting participants by invitation only.
  • The study status is unknown: the governmental institution has not received updates from the study designers.
  • The study protocol uses at least one method of stem cell therapy or stem cell stimulation.

Exclusion Criteria

We excluded studies that:

  • Are completed, terminated, or withdrawn.
  • Are not using stem cells or stem cell stimulation as a therapeutic method.

Search Results

We found four studies that follow our inclusion and exclusion criteria. You can find the names of the study protocols and a brief description of each in the section below.

Rh-PDGF vs EMD for Treatment of Intra-bony Defects

Intrabony defects are injuries to the alveolar bone, the supporting structure of the teeth root. This is usually due to periodontitis.

In this study, researchers compare recombinant human platelet-derived growth factor (Rh-PDGF) and enamel matrix derivatives (EMD). Both treatment groups use bone allograft (a bone graft from human subjects) in combination with Rh-PDGF or EMD.

Rh-PDGF is a molecule found in the blood. It has the capacity to recruit stem cells and aid in the regeneration and reconstruction of tissues.

EMD is found in normal tooth follicles, the surrounding tissue of growing teeth. EMD is known to help regenerate dental structures.

The aim of this study is to assess whether intrabony defects regenerate better using Rh-PDGF plus bone allograft or EMD plus bone allograft.

Dental Pulp Regeneration by Autologous Tissue Transplantation

Some people may experience dental pulp inflammation or infection. Dentists perform a procedure called a root canal to repair the damaged tissue and refill the tooth canal.

In this study, researchers aim to test if a damaged tooth canal can be repaired and healed by using dental pulp mesenchymal stem cells.

Progenitor Potential of Mesenchymal Stem Cells in Palatal Tissue Harvested From Molar and Premolar Sites

Gingival recession is a disorder in which gums fail to cover the teeth roots. This can cause pain and discomfort to people with this disorder.

The aim of this study is to collect gum tissue from the further back teeth (molar) and those which follow (premolar) to isolate mesenchymal stem cells. Then, scientists can investigate the behavior of these stem cells in order to repair gingival recession.

Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots

Pulp necrosis refers to the death of the pulp tissue. Pulp necrosis can occur after inflammation or infection of the pulp.

In this trial, scientists compare standard pulp repair with disinfection of the tooth canal plus material to help promote repair or disinfection plus enamel matrix derivatives. Similarly to the first study, researchers assess if enamel matrix derivatives are useful for repairing damaged teeth.


Dental regeneration is an active field of research with encouraging prospects for the future of dentistry.

Clinical trials are a critical step in developing new and better treatments for improving health. By getting to know the current research, you can make informed decisions and discuss the best treatment options for you with your dentist.

See Also

Does Medicaid Cover Dental Implants?

Medicare Dental Implants Coverage

Apply for Government Grants for Dental Implants

Does Medicare Cover Dental Implants?

Cosmetic Dentistry Grants Review 

Does Medicaid Cover Braces? How to Qualify?

Franco Cuevas is a physician who graduated from the National University of Córdoba, Argentina. He practices general medicine in the Emergency Department at Sanatorio de la Cañada, Córdoba. His focus is on writing medical content to improve physicians' access to relevant medical information for daily practice. He has participated in some research projects and has a special joy in teaching and writing about medical concepts.

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