Top 5 Melanoma Clinical Trials

Melanoma Clinical Trials – Overview

Melanoma is one of the most serious types of skin cancer. It develops in the melanocytes, cells that produce melanin. This is a pigment that gives color to your skin.

While melanoma most commonly develops in the skin, it can also occur in the eyes (ocular melanoma) and, less commonly, in internal organs such as the nasal passages, mouth, and genital and anal regions (mucosal melanoma).

Several advances have been made in combating melanoma by scientists across the globe.

To help researchers boost their knowledge and make their studies more effective, we have listed the top melanoma clinical trials.

5 Most Popular Melanoma Clinical Trials

Here is a list of currently active melanoma clinical trials in the United States:

1 – Study to See if New Device Technology can Tell the Difference between Non-Cancer and Cancerous Melanoma

Remove this sentence; it contains fictional elements (Balter Medical OTD technology).

The eligibility criteria for this clinical trial include gender, age, stage and type of disease along with previously-administered treatments or health issues.

Different studies have different guidelines for vetting participants. Not every individual who is eligible and wishes to participate in the trial will be enrolled.

Hence, it is recommended to contact the research team to discuss study eligibility and potential for participation.

The inclusion criteria for this study dictate the following:

  • Total of 300 participants in sets of 50 patients
  • Over 17 years of age
  • Confirmed consent
  • Biopsy or excision of suspicious pigmented lesions is planned

For more details on the enrollment process, it’s recommended to directly contact the research institutions or hospitals conducting the clinical trials.

2 – Study Comparing Temozolomide and Selumetinib for Treating Patients with Metastatic Melanoma of the Eye

This study aims to evaluate the effectiveness of temozolomide to selumetinib for treating patients suffering from melanoma of the eye, which has also spread to other places of the body.

These drugs are often used in chemotherapy but work in different ways to halt the growth of cancerous tumor cells.

These drugs work to either kill the cancerous cells or stop them from dividing further and cease their spread. Selumetinib is likely to stop the growth of tumor cells by restricting some of the enzymes required for cell growth.

The eligibility criteria for this study are extensive. The criteria dictate that the participant must have histologically or cytologically confirmed metastatic uveal melanoma.

It must be a measurable disease and defined by at least one lesion that can be accurately measured in at least one dimension.

The life expectancy of the participant should be greater than 3 months. Besides this, there are several other strict criteria regulating participation in this study.

For detailed eligibility criteria and application processes, prospective participants should directly contact the clinical trial’s research team.

3 – Study to Describe Patterns of Treatment, Demographics, Clinical Characteristics and Overall Survival in Patients with Unresectable or Metastatic Melanoma

The aim of this study is to describe the demographics, different patterns of patient care and clinical characteristics of patients who are suffering from unresectable or metastatic melanoma.

The duration, dosing, regimen, treatments and indication will be observed in this clinical trial.

The eligibility criteria for this study evaluate and choose participants on the basis of age, gender, type and stage of disease as well as previous treatments or health issues.

Different studies will have different guidelines, so make sure to check the relevant guidelines before applying to participate in any of these research trials.

Though there is no guarantee that every potential participant will be chosen for this trial, it is advisable to contact the research team to know how you can improve your chances of successfully participating in this clinical trial.

For more information, interested individuals should reach out directly to the research teams conducting these studies.

4 – Study of Immune System Activity Cycles in Patients with Surgically Removed Early-Stage Melanoma

This study aims to identify melanoma patients that show a pattern when their immune system is more active in fighting cancer cells. The trial will evaluate to see if treating melanoma at certain times in the cycle can be more effective.

The eligibility criteria for this trial study require participants to be at least 18 years old, with a history of early-stage malignant melanoma (Stages I, II or IIIA), a history of curative surgical reaction and willing to provide blood samples for research.

Pregnant or breastfeeding women are exempt from participating in this clinical trial.

For additional information on eligibility criteria and how to apply, contact the responsible research teams directly.

5 – Study of Effectiveness of Stress Management Therapy for Patients with Melanoma

This study aims to test a particular stress management therapy program to check its effectiveness in reducing stress, and improving the quality of life and the immune system in patients suffering from melanoma.

The eligibility criteria for this clinical trial require participants to have a current or new diagnosis of melanoma (from stage 0 to IV), be over 18 years old, be willing to participate in all aspects of the study and provide a consent form.

As there is no guarantee that every qualifying participant will be included in the study, it is advisable to contact the research team to increase your chances of successful participation.

You may be exempt from participation in this clinical trial if you have suffered from a psychotic episode in the past 6 months or are clinically deemed acutely unstable.

For further details about eligibility criteria and how to participate, potential participants should get in touch with the study’s research team.


There are numerous clinical trials conducted every month in different fields of medical science. Cancer research is one of the biggest and most expansive fields in medicine.

If you wish to contribute towards effective research and development of improved diagnostic, treatment and preventive measures, then you should definitely participate in a melanoma clinical trial.

Additional opportunities to participate in melanoma clinical trials can be found by searching reputable clinical trial databases or contacting research institutions directly.

See Also

Worldwide Clinical Trials

Covance Clinical Trials

Medical Device Clinical Trials

Dental Implant Clinical Trials

Current Version
August 9, 2022
Written By
Shubham Grover
March 21, 2024
Updated By
Andleeb Asghar, PharmD

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