Melanoma Clinical Trials ā Overview
Melanoma is one of the most serious types of skin cancer. It develops in the melanocytes, cells that produce melanin. This is a pigment that gives color to your skin.
While melanoma most commonly develops in the skin, it can also occur in the eyes (ocular melanoma) and, less commonly, in internal organs such as the nasal passages, mouth, and genital and anal regions (mucosal melanoma).
Several advances have been made in combating melanoma by scientists across the globe.
To help researchers boost their knowledge and make their studies more effective, we have listed the top melanoma clinical trials.
5 Most Popular Melanoma Clinical Trials
Here is a list of currently active melanoma clinical trials in the United States:
1 ā TILVANCE-301 ā Lifileucel (TIL Therapy) + Pembrolizumab vs. Pembrolizumab in Advanced Melanoma (Phase III)
A Phase III trial testing if adding lifileucel to first-line pembrolizumab improves outcomes in untreated unresectable or metastatic melanoma. Enrolling U.S. patients age 18+, no prior systemic therapy.
2 ā PRISM-MEL-301 ā Brenetafusp (IMC-F106C) + Nivolumab vs. Nivolumab in HLA-A*02:01-Positive Melanoma (Phase III)
A Phase III trial evaluating brenetafusp with nivolumab vs. standard immunotherapy in previously untreated advanced melanoma. HLA-A*02:01-positive required.
3 ā RP2-202 (REVEAL Trial) ā Oncolytic Virus (RP2) + Nivolumab vs. Ipilimumab + Nivolumab in Metastatic Uveal Melanoma (Phase II/III)
Tests RP2 virus + nivolumab vs. ipilimumab + nivolumab in metastatic uveal melanoma. Includes patients with injectable tumors and no prior checkpoint inhibitors.
4 ā Ac-225-MTI-201 ā Actinium-225 Radiopharmaceutical Trial in Metastatic Uveal Melanoma (Phase I)
A first-in-human study using targeted alpha therapy with Ac-225-MTI-201 in metastatic uveal melanoma post-progression. Single dose, monitored for safety.
5 ā Study of Effectiveness of Stress Management Therapy for Patients with Melanoma
WTX-124 ā Tumor-Targeted IL-2 Prodrug (INDUKINEā¢) Trial in Advanced Melanoma (Phase I/1b)
Trial for patients with advanced/metastatic melanoma using WTX-124, a tumor-activated IL-2 therapy, alone or with pembrolizumab. For those who have progressed on prior treatments.
Conclusion
Numerous clinical trials are conducted every month in various fields of medical science. Cancer research is one of the biggest and most expansive fields in medicine.
If you wish to contribute towards effective research and development of improved diagnostic, treatment and preventive measures, then you should definitely participate in a melanoma clinical trial.
Additional opportunities to participate in melanoma clinical trials can be found by searching reputable clinical trial databases or contacting research institutions directly.
See Also
