4 Leading Cancer Clinical Trials

Leading Cancer Clinical Trials

Cancer is one of the most dangerous and prevalent disorders today. Scientists and medical professionals have been trying to find out more effective and efficient ways not just to diagnose and treat cancer but also how to prevent it.

Tens of thousands of scientists across the world are currently engaged in cancer research. If you too want to make a contribution towards this and help find better diagnostic and treatment methods for cancer, you can follow the links provided below.

Where to find Cancer Clinical Trials in the US?

The National Cancer Institute (NCI) is the leading federal health organization engaged in everything related to cancer in the US. Here are some of NCI’s top current cancer clinical trials:

Where to find Cancer Clinical Trials in the US

Where to find Cancer Clinical Trials in the US

1 – NCI-COG Pediatric MATCH

The NCI-COG Pediatric MATCH is a country-wide cancer treatment clinical trial aimed at adolescents and children between 1 and 21 years old. This cancer clinical trial aims to test the use of precision medicine for pediatric cancer care.

This trial will accommodate patients suffering from solid tumors with no response to treatment and allot them an experimental treatment technique based on genetic changes developing in the cancer cells as opposed to treating the tumor according to the type of cancer or the location of cancer.

In essence, this cancer clinical trial aims to find the effectiveness of treating cancer tumors in children and adolescents by focusing on specific genetic changes which can be treated using medicinal drugs.

For additional information on eligibility criteria and application process, feel free to consult your child’s doctors and healthcare team and then contact Pediatric MATCH for more details at https://www.cancer.gov/about-cancer/treatment/

2 – NCI-MATCH Trial (Molecular Analysis for Therapy Choice)

NCI-MATCH, also known as MATCH, in short, is a precision medicine treatment cancer clinical trial. This trial aims to discover and determine the effectiveness of treating cancer through genetically modifying the cancer cells using genomic sequencing and other similar methods.

If the participant meets the eligibility criteria and suffers from cancer that displays genetic mutation at the cellular level, then the participant will be treated using specified genome enhancing drugs.

This trial contains several different categories, based on the specific type of cancer that the participant has. This trial is set to use only FDA-approved medicinal drugs or drugs that have shown promising effects to combat cancer growth.

To learn further details of this cancer clinical trial, feel free to consult your doctor of healthcare team first before learning more through the NCI official website at https://www.cancer.gov/about-cancer/treatment/nci-supported/nci-match.

3 – ALCHEMIST Lung Cancer Trial

The Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials, or ALCHEMIST, in short, is a series of randomized cancer clinical trials for patients suffering from early-stage non-small cell lung cancer (NSCLC) and whose tumors have been removed successfully through surgical treatment.

This trial aims to determine whether adding targeted therapy according to the patient’s tumor genetics will be effective to prevent cancer from recurring and in a sense, help elongate the patient’s lifespan.

Some of the top ALCHEMIST Cancer Trials include:

  • ALCHEMIST Screening Trial – This specific cancer clinical trial is aimed at determining the best trial for patients by examining a sample of their tumor. If a patient tests positive for EGFR mutations and ALK re-arrangements then they will be referred to a trial which is testing the effectiveness of erlotinib and crizotinib for correcting the condition. Those without EGFR alterations and ALK re-arrangements will be referred to an immunotherapy trial using the nivolumab drug.
  • ALCHEMIST EGFR Treatment Trial – The EGFR Treatment Trial is aimed at testing the effectiveness of erlotinib on patients suffering from tumors with EGFR mutation. This cancer clinical trial is aimed to determine whether erlotinib improves overall survival as compared to a placebo in patients suffering from early-stage EGFR-positive NSCLC and who have completed successful surgical tumor removal.
  • ALCHEMIST ALK Treatment Trial – The ALK Treatment Trial aims to treat patients suffering from NSCLC tumors showing ALK re-arrangement using the crizotinib drug. This cancer clinical trial is set to determine the effectiveness of using crizotinib in patients suffering from early-stage ALK-positive NSCLC after successful surgical removal of the tumor.

4 – Lung-MAP – Master Protocol for Lung Cancer

The Lung-MAP trial, also known as Lung Cancer Master Protocol is a precision medicine cancer clinical trial.

This trial is in search of people who are suffering from advanced non-small cell lung cancer (NSCLC) which is growing despite ongoing treatment.

This is an umbrella trial and will include the testing of several different types of medicinal drugs.

The Lung-MAP cancer clinical trial aims to test different treatment methods that focus on genetic changes in NSCLC. This trial is set to take place at over 700 locations across the US.

If you are interested in participating in this trial, you need to talk to your doctor or healthcare team before finding out more about this trial at their official website https://www.cancer.gov/types/lung/research/lung-map.


These are the top current cancer clinical trials being held across the US.

There are numerous other opportunities for cancer patients to participate in similar trials and make their contribution towards improving and enhancing cancer diagnostic and treatment methods.

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